abstract：:Epileptic seizures in diabetic hyperglycemia (DH) are not uncommon. This study aimed to determine the acute behavioral, pathological, and electrophysiological effects of status epilepticus (SE) on diabetic animals. Adult male Sprague-Dawley rats were first divided into groups with and without streptozotocin (STZ)-indu...

journal_title：Neurotoxicity research

authors： Huang CW,Cheng JT,Tsai JJ,Wu SN,Huang CC

更新日期：2009-01-01 00:00:00

abstract：:GSK3beta is prominent for its role in apoptosis signaling and has been shown to be involved in Parkinson's disease (PD) pathogenesis. The overall effects of GSK3beta activity on cell fate are well-established, but the effects of mitochondrial GSK3beta activity on mitochondrial function and cell fate are unknown. Here ...

journal_title：Neurotoxicity research

authors： King TD,Clodfelder-Miller B,Barksdale KA,Bijur GN

更新日期：2008-12-01 00:00:00

abstract：:The process of receptor supersensitivity (RSS) has a long history and is an epiphenomenon of neuronal denervation. Dopamine (DA) RSS (DARSS) similarly occurs after DA denervation, and this process is invoked in neuropsychiatric and neurodegenerative disorders. From studies largely over the past 25 years, much has been...

journal_title：Neurotoxicity research

authors： Kostrzewa RM,Kostrzewa JP,Brown RW,Nowak P,Brus R

更新日期：2008-10-01 00:00:00

abstract：:There is a long-standing debate about whether rats have what could be considered a prefrontal cortex (PFC) and, if they do, what its primate homologue is. Anatomical evidence supports the view that the rat medial PFC is related to both the primate anterior cingulate cortex (ACC) and the dorsolateral PFC. Functionally ...

journal_title：Neurotoxicity research

authors： Seamans JK,Lapish CC,Durstewitz D

更新日期：2008-10-01 00:00:00

abstract：:Neuronal cell death caused by pathophysiological over-activation of glutamate receptors and the subsequent CaII overloading, has been implicated in neurodegeneration after stroke, cerebral trauma and epileptic seizures. Recent findings suggest that certain progesterone metabolites (neurosteroids) such as allopregnanol...

journal_title：Neurotoxicity research

authors： Xilouri M,Papazafiri P

更新日期：2008-05-01 00:00:00

abstract：:To determine whether noradrenergic nerves might have a modulatory role on the sensitivity or reactivity of histaminergic receptor systems in brain, behavioral effects of the respective histamine H1, H2 and H3 antagonists S(+)chlorpheniramine, cimetidine and thioperimide in control adult rats were compared to the effec...

journal_title：Neurotoxicity research

authors： Nowak P,Jochem J,Zwirska-Korczala K,Josko J,Noras L,Kostrzewa RM,Brus R

更新日期：2008-04-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease resulting from the progressive loss of motor neurons in the spinal cord and brain. To date, clinically effective neuroprotective agents have not been available. The current study demonstrates for the first time that huperzine A, a potential neuroprotec...

journal_title：Neurotoxicity research

authors： Hemendinger RA,Armstrong EJ 3rd,Persinski R,Todd J,Mougeot JL,Volvovitz F,Rosenfeld J

更新日期：2008-01-01 00:00:00

abstract：:Alzheimer disease (AD) is a major cause of dementia. Several mechanisms have been postulated to explain its pathogenesis, beta-amyloid (A beta toxicity, cholinergic dysfunction, Tau hyper-phosphorylation, oxidative damage, synaptic dysfunction and inflammation secondary to senile plaques, among others. Glial cells are...

journal_title：Neurotoxicity research

authors： von Bernhardi R

更新日期：2007-12-01 00:00:00

abstract：:Aluminum (Al), a known neurotoxin, has been implicated in Alzheimer's Disease (AD), Amyotrophic Lateral Sclerosis (ALS), Parkinsonism Dementia Complex, etc., and it causes extensive damage to the nervous system, including the impairment of learning and memory. However, to date, the mechanism of Al neurotoxicity has no...

journal_title：Neurotoxicity research

authors： Niu Q,Yang Y,Zhang Q,Niu P,He S,Di Gioacchino M,Conti P,Boscolo P

更新日期：2007-10-01 00:00:00

abstract：:Salsolinol (1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline), a metabolite of dopamine, may act as an endogenous neurotoxin and contribute to the etiology of Parkinson's disease (PD). The inverse relationship between smoking and PD prompted our previous investigation and the report of protective effects of nicot...

journal_title：Neurotoxicity research

authors： Copeland RL Jr,Das JR,Kanaan YM,Taylor RE,Tizabi Y

更新日期：2007-07-01 00:00:00

abstract：:Neurotransmitters and neuromodulators are essential for normal nervous system development. Disturbances in the expression timetable or intensity of neurotransmitter signalling during critical periods of brain development can lead to permanent damage. Neuroactive drugs and environmental toxins interfere with neurotrans...

journal_title：Neurotoxicity research

authors： Kaindl AM,Ikonomidou C

更新日期：2007-04-01 00:00:00

abstract：:Depression is common in patients with schizophrenia and it is well established from family studies that rates of depression are increased among relatives of probands with schizophrenia, making it likely that the phenotypes described under the categories of affective and non-affective psychoses share some genetic risk ...

journal_title：Neurotoxicity research

authors： Blackwood DH,Pickard BJ,Thomson PA,Evans KL,Porteous DJ,Muir WJ

更新日期：2007-01-01 00:00:00

abstract：:Hyperfunction of brain dopamine (DA) systems is associated with psychosis in schizophrenia and the medications used to treat schizophrenia are DA receptor blockers. DA also plays a critical role in incentive learning produced by rewarding stimuli. Using DA as the link, these results suggest that psychosis in schizophr...

journal_title：Neurotoxicity research

authors： Beninger RJ

更新日期：2006-12-01 00:00:00

abstract：:Cognitive impairment in depression may be one of the more practically important aspects of the illness, responsible for much of its morbidity. It also is at the heart of its psychopathology, may contribute to strategies of treatment, and may give us a more easily quantifiable measure of impaired function to correlate ...

journal_title：Neurotoxicity research

authors： Ebmeier K,Rose E,Steele D

更新日期：2006-10-01 00:00:00

abstract：:Autism was recently associated with a urinary porphyrin pattern indicative of mercury toxicity in a large cohort of French children. The IRB of the Institute for Chronic Illnesses approved the present study. A total of 37 consecutive American patients (> or = 7 years-old) with autism spectrum disorders (ASDs) (Diagnos...

journal_title：Neurotoxicity research

authors： Geier DA,Geier MR

更新日期：2006-08-01 00:00:00

abstract：:C57/BL6 mice were administered either 7.5 mg Fe (II)/ kg or vehicle (saline) postnatally on Days 10-12 after birth. From 64 days of age onwards for 24 days, groups of mice were administered either haloperidol (0.25 or 1 or 2 mg/kg, s.c.) or vehicle (Tween-80). Twenty-four hours after the final injection of either neur...

journal_title：Neurotoxicity research

authors： Fredriksson A,Archer T

更新日期：2006-06-01 00:00:00

abstract：:Botulinum neurotoxin (BoNT) has been used clinically since 1980, with an ever-increasing range of clinical applications. This has coincided with a period of massively expanded interest in the underlying biology of the neurotoxin. Tremendous advances have taken place in the scientific understanding of neurotoxin struct...

journal_title：Neurotoxicity research

authors： Foster KA,Bigalke H,Aoki KR

更新日期：2006-04-01 00:00:00

abstract：:Curcumin, a natural polyphenolic compound, has long been known as an anti-tumour and anti-inflammatory compound; although, the common mechanism through which it exhibits such properties are remains unclear. Recently, we reported that the curcumin-induced apoptosis is mediated through the impairment of ubiquitin protea...

journal_title：Neurotoxicity research

authors： Dikshit P,Goswami A,Mishra A,Chatterjee M,Jana NR

更新日期：2006-01-01 00:00:00

abstract：:The mitochondrial toxin, 3-nitropropionic acid (3-NP), produces motor dysfunction and striatal atrophy in rats. However, rat strain and method of administration may contribute to variability in the deficits caused by 3-NP toxicity. To evaluate this, changes in nocturnal spontaneous locomotor activity from chronic admi...

journal_title：Neurotoxicity research

authors： Newcomb JD,Brown WD,Rodriguez AI,Garbuzova-Davis S,Saporta S,Sanberg PR,Willing AE

更新日期：2005-11-01 00:00:00

abstract：:The deaths of neurons, astrocytes and endothelial cells have been described in patients with HIV (human immunodeficiency virus) dementia. HIV-1 does not infect neurons; instead, neurotoxic substances shed by infected glia and macrophages can induce a form of programmed cell death called apoptosis in neurons. These neu...

journal_title：Neurotoxicity research

authors： Li W,Galey D,Mattson MP,Nath A

更新日期：2005-10-01 00:00:00

abstract：:Multiple system atrophy (MSA) is characterized by the formation of oligodendroglial cytoplasmic inclusions (GCIs) consisting of alpha-synuclein filaments. AlphaB-crystallin, a small chaperone protein that binds to unfolded proteins and inhibits aggregation, has been documented in GCIs. We investigated the relative abu...

journal_title：Neurotoxicity research

authors： Pountney DL,Treweek TM,Chataway T,Huang Y,Chegini F,Blumbergs PC,Raftery MJ,Gai WP

更新日期：2005-01-01 00:00:00

abstract：:The possible link between tau phosphorylation and tau assembly in these neurodegenerative diseases known as tauopathies is described. Additionally, this link is supported by an in vitro experiment showing the higher capacity of phosphotau to assemble in some specific conditions; and, by a recently reported experiment ...

journal_title：Neurotoxicity research

authors： Avila J,Pérez M,Lim F,Gómez-Ramos A,Hernández F,Lucas JJ

更新日期：2004-01-01 00:00:00

abstract：:Multiple lines of evidence demonstrate that reactive oxygen species (ROS) are involved in regulation of normal cell metabolism as second messengers. Under extreme conditions, these molecules induce oxidative stress, which may stimulate (or accompany) a number of neurodegenerative processes. In the glutamatergic system...

journal_title：Neurotoxicity research

authors： Boldyrev A,Bulygina E,Makhro A

更新日期：2004-01-01 00:00:00

abstract：:The present study shows that intranigral injection of dicoumarol, a DT-diaphorase inhibitor, potentiates the neurotoxic effect of salsolinol (salsolinol 1.25 nmoles plus dicoumarol 2 nmoles; in 2 microl). Rats treated with dicoumarol plus salsolinol presented a characteristic contralateral rotational behaviour when th...

journal_title：Neurotoxicity research

authors： Díaz-Véliz G,Mora S,Lungenstrass H,Segura-Aguilar J

更新日期：2004-01-01 00:00:00

abstract：:In the last decade, a large number of studies using Delta9-tetrahydrocannabinol (THC), the main active principle derivative of the marijuana plant, or cannabinoid synthetic derivatives have substantially contributed to advance the understanding of the pharmacology and neurobiological mechanisms produced by cannabinoid...

journal_title：Neurotoxicity research

authors： Manzanares J,Urigüen L,Rubio G,Palomo T

更新日期：2004-01-01 00:00:00

abstract：:Genetic studies have sought to identify subtypes or endophenotypes of schizophrenia in an effort to improve the reliability of findings. A number of chromosomal regions or genes have now been shown to have had replicated linkage to schizophrenia susceptibility. Molecules involved in neurodevelopment or neurotransmitte...

journal_title：Neurotoxicity research

authors： Palomo T,Archer T,Kostrzewa RM,Beninger RJ

更新日期：2004-01-01 00:00:00

abstract：:Reward-related incentive learning involves the acquisition by neutral stimuli of an enhanced ability to elicit approach and other responses. Previous studies have shown that both dopamine (DA) and glutamate (Glu) play critical roles in this type of learning. Signaling molecules are intracellular messengers that partic...

journal_title：Neurotoxicity research

authors： Beninger RJ,Gerdjikov T

更新日期：2004-01-01 00:00:00

abstract：:Leaner mice carry a homozygous, autosomal recessive mutation in the mouse CACNA1A gene encoding the Alpha1A subunit of P/Q-type calcium channels, which results in an out-of-frame splicing event in the carboxy terminus of the Alpha1A protein. Leaner mice exhibit severe ataxia, paroxysmal dyskinesia and absence seizures...

journal_title：Neurotoxicity research

authors： Lau FC,Frank TC,Nahm SS,Stoica G,Abbott LC

更新日期：2004-01-01 00:00:00

abstract：:The TaqIA1 allele of the dopamine receptor gene D2 (DRD2) has been associated with alcoholism, as well as with other addictive behaviours. The exact nature of how the presence of this allele can be a vulnerability factor in the development of alcoholism remains unclear. In this study we found that the presence in the ...

journal_title：Neurotoxicity research

authors： Ponce G,Hoenicka J,Rodríguez-Jiménez R,Gozalo A,Jimenéz M,Monasor R,Aragüés M,Rubio G,Jiménez-Arriero MA,Ramos JA,Palomo T

更新日期：2004-01-01 00:00:00

abstract：:Accumulating data support axonal degeneration as the major determinant of irreversible neurological disability in patients with multiple sclerosis (MS). The extent of axonal injury correlates with the degree of inflammation in active MS lesions and occurs at early stages of disease, indicating that inflammatory demyel...

journal_title：Neurotoxicity research

authors： Bjartmar C,Trapp BD

更新日期：2003-01-01 00:00:00

abstract：:Cellular mechanisms involved in neurodegeneration and neuroprotection are continuing to be explored, and this paper focuses on some novel discoveries that give further insight into these processes. Oligodendrocytes and activated astroglia are likely generators of the pro-inflammatory cytokines, such as the tumor necro...

journal_title：Neurotoxicity research

authors： Kostrzewa RM,Segura-Aguilar J

更新日期：2003-01-01 00:00:00

abstract：:Alcoholism is associated with a higher incidence of smoking. In addition to the stimulatory effects of both ethanol and nicotine on the mesolimbic reward pathway, nicotine's ability to counteract some of the adverse effects of ethanol (e.g. ataxia) may be a powerful incentive for alcohol consumers to increase their to...

journal_title：Neurotoxicity research

authors： Tizabi Y,Al-Namaeh M,Manaye KF,Taylor RE

更新日期：2003-01-01 00:00:00

abstract：:Mercury is a ubiquitous contaminant, and a range of chemical species is generated by human activity and natural environmental change. Elemental mercury and its inorganic and organic compounds have different toxic properties, but all them are considered hazardous in human exposure. In an equimolecular exposure basis, o...

journal_title：Neurotoxicity research

authors： Sanfeliu C,Sebastià J,Cristòfol R,Rodríguez-Farré E

更新日期：2003-01-01 00:00:00

abstract：:Methamphetamine (METH) is an illicit drug that is also neurotoxic. Recent studies suggest that in addition to dopamine terminal degeneration in the striatum, METH causes apoptosis in cortical neurons. Earlier, we showed that c-fos knockout mice are more susceptible to the toxic effects of the drug. In order to identif...

journal_title：Neurotoxicity research

authors： Betts ES,Krasnova IN,McCoy MT,Ladenheim B,Cadet JL

更新日期：2002-11-01 00:00:00

abstract：:In the context of our current knowledge about schizophrenia, heuristic models of psychiatric disorders may be used to test the plausibility of theories developed on the basis of new emerging biological findings, explore mechanisms of schizophrenia-like phenomena, and develop potential new treatments. In a series of st...

journal_title：Neurotoxicity research

authors： Lipska BK,Weinberger DR

更新日期：2002-08-01 00:00:00

abstract：:Depressive symptomatology is expressed across a wide spectrum of psychiatric disorders including major depression and schizophrenia. Further, depressive symptomatology is also observed in individuals undergoing withdrawal from chronic exposure to various drugs of abuse including cocaine, amphetamine and nicotine. The ...

journal_title：Neurotoxicity research

authors： Markou A,Kenny PJ

更新日期：2002-06-01 00:00:00

abstract：:Maillard reactions have been explored by food chemists for many years. It is only recently that the advanced glycation end products (AGEs), the end products of the Maillard reaction, have been detected in a wide variety of diseases such as diabetes, atherosclerosis, cataractogenesis, Parkinson disease and Alzheimer di...

journal_title：Neurotoxicity research

authors： Reddy VP,Obrenovich ME,Atwood CS,Perry G,Smith MA

更新日期：2002-05-01 00:00:00

abstract：:Neural transplantation is a promising treatment strategy that can restore the motor, sensory and cognitive functions in the rat middle cerebral artery occlusion (MCAO) model of stroke. In particular, neuronal cells derived from a human teratocarcinoma cell line, called hNT neurons or LBS neurons (clinical grade prepar...

journal_title：Neurotoxicity research

authors： Willing AE,Saporta S,Lixian J,Milliken M,Poulos S,Bowersox SS,Sanberg PR

更新日期：2002-03-01 00:00:00

abstract：:The isolated sciatic nerve of the frog was used to assess the effects of the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) on the peripheral nervous system. For each experiment, both sciatic nerves were used. The evoked compound action potentials of the nerves were monitored for over 48 h as an indication of their ...

journal_title：Neurotoxicity research

authors： Kouri G,Theophilidis G

更新日期：2002-02-01 00:00:00

abstract：:Functional role(s) for the common neurotrophin receptor p75NTR in nerve growth factor (NGF) signaling have yet to be fully elucidated. Many studies have demonstrated that p75NTR can enhance nerve growth factor-induced survival mediated via the trkA receptor. In addition, newly identified pathways for p75NTR signaling ...

journal_title：Neurotoxicity research

authors： Wang W,Dow KE,Riopelle RJ,Ross GM

更新日期：2001-10-01 00:00:00